Uridylation prevents 3′ trimming of oligoadenylated mRNAs

Degradation of mRNAs is usually initiated by deadenylation, the shortening of long poly(A) tails to oligo(A) tails of 12–15 As. Deadenylation leads to decapping and to subsequent 5′ to 3′ degradation by XRN proteins, or alternatively 3′ to 5′ degradation by the exosome. Decapping can also be induced...

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Autores principales: Sement, François Michaël, Ferrier, Emilie, Zuber, Hélène, Merret, Rémy, Alioua, Malek, Deragon, Jean-Marc, Bousquet-Antonelli, Cécile, Lange, Heike, Gagliardi, Dominique
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737552/
https://ncbi.nlm.nih.gov/pubmed/23748567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt465
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