Uridylation prevents 3′ trimming of oligoadenylated mRNAs

Degradation of mRNAs is usually initiated by deadenylation, the shortening of long poly(A) tails to oligo(A) tails of 12–15 As. Deadenylation leads to decapping and to subsequent 5′ to 3′ degradation by XRN proteins, or alternatively 3′ to 5′ degradation by the exosome. Decapping can also be induced...

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Dades bibliogràfiques
Autors principals: Sement, François Michaël, Ferrier, Emilie, Zuber, Hélène, Merret, Rémy, Alioua, Malek, Deragon, Jean-Marc, Bousquet-Antonelli, Cécile, Lange, Heike, Gagliardi, Dominique
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737552/
https://ncbi.nlm.nih.gov/pubmed/23748567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt465
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