Comparison of IHC, FISH and RT-PCR Methods for Detection of ALK Rearrangements in 312 Non-Small Cell Lung Cancer Patients in Taiwan

BACKGROUND: Recently Echinoderm microtubule-associated protein-like 4- anaplastic lymphoma kinase (EML4-ALK) fusion gene has become an important biomarker for ALK tyrosine kinase inhibitor (crizotinib) treatment in NSCLC. However, the best detection method and the significance of EML4-ALK variant ty...

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Main Authors: Wu, Yi-Cheng, Chang, Il-Chi, Wang, Chi-Liang, Chen, Tai-Di, Chen, Ya-Ting, Liu, Hui-Ping, Chu, Yen, Chiu, Yu-Ting, Wu, Tzu-Hua, Chou, Li-Hui, Chen, Yi-Rong, Huang, Shiu-Feng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737393/
https://ncbi.nlm.nih.gov/pubmed/23951022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070839
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