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Evolutionarily Stable Attenuation by Genome Rearrangement in a Virus

Live, attenuated viruses provide many of the most effective vaccines. For the better part of a century, the standard method of attenuation has been viral growth in novel environments, whereby the virus adapts to the new environment but incurs a reduced ability to grow in the original host. The downs...

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Autors principals: Cecchini, Nicole, Schmerer, Matthew, Molineux, Ian J., Springman, Rachael, Bull, James J.
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737178/
https://ncbi.nlm.nih.gov/pubmed/23797106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.113.006403
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