Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells

Human Rhinovirus (HRV) infection results in shut down of essential cellular processes, in part through disruption of nucleocytoplasmic transport by cleavage of the nucleoporin proteins (Nups) that make up the host cell nuclear pore. Although the HRV genome encodes two proteases (2A and 3C) able to c...

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Détails bibliographiques
Auteurs principaux: Walker, Erin J., Younessi, Parisa, Fulcher, Alex J., McCuaig, Robert, Thomas, Belinda J., Bardin, Philip G., Jans, David A., Ghildyal, Reena
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737158/
https://ncbi.nlm.nih.gov/pubmed/23951130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071316
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