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The Curcumin Analog EF24 Targets NF-κB and miRNA-21, and Has Potent Anticancer Activity In Vitro and In Vivo

EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its therapeutic potential and mechanism of action is unknown, which is important to address as curcumin targets multiple signaling pathways. EF24 inhibits the NF-κB but not the JAK-STAT signaling pathway in DU145 huma...

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Bibliografische gegevens
Hoofdauteurs: Yang, Chuan He, Yue, Junming, Sims, Michelle, Pfeffer, Lawrence M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737134/
https://ncbi.nlm.nih.gov/pubmed/23940701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071130
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