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The Curcumin Analog EF24 Targets NF-κB and miRNA-21, and Has Potent Anticancer Activity In Vitro and In Vivo

EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its therapeutic potential and mechanism of action is unknown, which is important to address as curcumin targets multiple signaling pathways. EF24 inhibits the NF-κB but not the JAK-STAT signaling pathway in DU145 huma...

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Detalhes bibliográficos
Main Authors: Yang, Chuan He, Yue, Junming, Sims, Michelle, Pfeffer, Lawrence M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737134/
https://ncbi.nlm.nih.gov/pubmed/23940701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071130
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