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SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

Neurotransmitters are released thru nascent fusion pores, which ordinarily dilate after bilayer fusion, preventing consistent biochemical studies. Here, we employ lipid bilayer nanodiscs as fusion partners, whose rigid protein framework prevents dilation and reveals properties of the SNARE-induced f...

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Detalhes bibliográficos
Main Authors: Shi, Lei, Shen, Qing-Tao, Kiel, Alexander, Wang, Jing, Wang, Hong-Wei, Melia, Thomas J., Rothman, James E., Pincet, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736847/
https://ncbi.nlm.nih.gov/pubmed/22422984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214984
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