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Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR Approach

The very amino-terminal domain of the huntingtin protein is directly located upstream of the protein’s polyglutamine tract, plays a decisive role in several important properties of this large protein and in the development of Huntington’s disease. This huntingtin 1–17 domain is on the one hand known...

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Autors principals: Michalek, Matthias, Salnikov, Evgeniy S., Bechinger, Burkhard
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736738/
https://ncbi.nlm.nih.gov/pubmed/23931318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.06.030
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