Islet1 Deletion Causes Kidney Agenesis and Hydroureter Resembling CAKUT

Islet1 (Isl1) is a transcription factor transiently expressed in a subset of heart and limb progenitors. During studies of limb development, conditional Isl1 deletion produced unexpected kidney abnormalities. Here, we studied the renal expression of Isl1 and whether it has a role in kidney developme...

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Autors principals: Kaku, Yusuke, Ohmori, Tomoko, Kudo, Kuniko, Fujimura, Sayoko, Suzuki, Kentaro, Evans, Sylvia M., Kawakami, Yasuhiko, Nishinakamura, Ryuichi
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2013
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736711/
https://ncbi.nlm.nih.gov/pubmed/23641053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050528
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