Androgen-Sensitive Hypertension Associates with Upregulated Vascular CYP4A12–20-HETE Synthase

Although the mechanism underlying the effect of androgen on BP and cardiovascular disease is not well understood, recent studies suggest that 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a primary cytochrome P450 4 (Cyp4)–derived eicosanoid, may mediate androgen-induced hypertension. Here,...

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Autors principals: Wu, Cheng-Chia, Mei, Shaojun, Cheng, Jennifer, Ding, Yan, Weidenhammer, Adam, Garcia, Victor, Zhang, Fan, Gotlinger, Katherine, Manthati, Vijaya L., Falck, John R., Capdevila, Jorge H., Schwartzman, Michal L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2013
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736709/
https://ncbi.nlm.nih.gov/pubmed/23641057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012070714
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