Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized (13)C-pyruvate magnetic resonance spectroscopy of tumors

Hyperpolarized 13C magnetic resonance spectroscopy (MRS) provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here we show that pharmacological inhibition of lactate dehydrogenase A suppressed the conversion of hyperpolarized...

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Hlavní autoři: Dutta, Prasanta, Le, Anne, Vander Jagt, David L., Tsukamoto, Takashi, Martinez, Gary V., Dang, Chi V., Gillies, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736580/
https://ncbi.nlm.nih.gov/pubmed/23722553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0465
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