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Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized (13)C-pyruvate magnetic resonance spectroscopy of tumors
Hyperpolarized 13C magnetic resonance spectroscopy (MRS) provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here we show that pharmacological inhibition of lactate dehydrogenase A suppressed the conversion of hyperpolarized...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3736580/ https://ncbi.nlm.nih.gov/pubmed/23722553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0465 |
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