KIR3DL2 binds to HLA-B27 dimers and free heavy chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis

The Human Leukocyte Antigen HLA-B27(B27) is strongly associated with the spondyloarthritides. B27 can be expressed at the cell surface of antigen presenting cells (APC) as both classical β2m-associated B27 and as B27 free heavy chain forms (FHC) including disulphide-bonded heavy chain homodimers (te...

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Bibliografiske detaljer
Main Authors: Wong-Baeza, Isabel, Ridley, Anna, Shaw, Jackie, Hatano, Hiroko, Rysnik, Oliwia, McHugh, Kirsty, Piper, Christopher, Brackenbridge, Simon, Fernandes, Ricardo, Chan, Anthoni, Bowness, Paul, Kollnberger, Simon
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736094/
https://ncbi.nlm.nih.gov/pubmed/23440420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202926
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