Induction of prolonged early G(1) arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1

Phosphatidylinositol-3-kinase (PI3K) signaling is constitutive in most human cancers. Selective inhibition of PI3Kδ (p110δ) by GS-1101 has emerged as a promising therapy in chronic lymphocytic leukemia and indolent lymphomas. In aggressive non-Hodgkin lymphomas such as mantle cell lymphoma (MCL), ho...

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Huvudupphovsmän: Chiron, David, Martin, Peter, Di Liberto, Maurizio, Huang, Xiangao, Ely, Scott, Lannutti, Brian J., Leonard, John P., Mason, Christopher E., Chen-Kiang, Selina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735703/
https://ncbi.nlm.nih.gov/pubmed/23676220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24928
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