Phenotypic Switching Induced by Damaged Matrix Is Associated with DNA Methyltransferase 3A (DNMT3A) Activity and Nuclear Localization in Smooth Muscle Cells (SMC)

Extracellular matrix changes are often crucial inciting events for fibroproliferative disease. Epigenetic changes, specifically DNA methylation, are critical factors underlying differentiated phenotypes. We examined the dependency of matrix-induced fibroproliferation and SMC phenotype on DNA methylt...

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Detalhes bibliográficos
Main Authors: Jiang, Jia-Xin, Aitken, Karen J., Sotiropolous, Chris, Kirwan, Tyler, Panchal, Trupti, Zhang, Nicole, Pu, Shuye, Wodak, Shoshana, Tolg, Cornelia, Bägli, Darius J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735580/
https://ncbi.nlm.nih.gov/pubmed/24282625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069089
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