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Protected Graft Copolymer Excipient Leads to a Higher Acute Maximum Tolerated Dose and Extends Residence Time of Vasoactive Intestinal Peptide Significantly Better than Sterically Stabilized Micelles

PURPOSE: To determine and compare pharmacokinetics and toxicity of two nanoformulations of Vasoactive Intestinal Peptide (VIP). METHODS: VIP was formulated using a micellar (Sterically Stabilized Micelles, SSM) and a polymer-based (Protected Graft Copolymer, PGC) nanocarrier at various loading perce...

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書誌詳細
主要な著者: Reichstetter, Sandra, Castillo, Gerardo M., Rubinstein, Israel, Nishimoto-Ashfield, Akiko, Lai, ManShun, Jones, Cynthia C., Banjeree, Aryamitra, Lyubimov, Alex, Bloedow, Duane C., Bogdanov, Alexei, Bolotin, Elijah M.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734960/
https://ncbi.nlm.nih.gov/pubmed/23224976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0904-4
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