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Neuroglobin upregulation induced by 17β-estradiol sequesters cytocrome c in the mitochondria preventing H(2)O(2)-induced apoptosis of neuroblastoma cells

The sex steroid hormone 17β-estradiol (E2) upregulates the levels of neuroglobin (NGB), a new neuroprotectant globin, to elicit its neuroprotective effect against H(2)O(2)-induced apoptosis. Several mechanisms could be proposed to justify the NGB involvement in E2 prevention of stress-induced apopto...

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Detalhes bibliográficos
Main Authors: De Marinis, E, Fiocchetti, M, Acconcia, F, Ascenzi, P, Marino, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734830/
https://ncbi.nlm.nih.gov/pubmed/23429294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.30
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