Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells

The potent and selective proteasome inhibitor bortezomib has shown remarkable antitumor activity and is now entering clinical trials for several cancers. However, the molecular mechanisms by which bortezomib induces cytotoxicity in ovarian cancer cells still remain unclear. In this study, we show th...

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Hlavní autoři: Kao, C, Chao, A, Tsai, C L, Lin, C Y, Chuang, W C, Chen, H W, Yen, T C, Wang, T H, Lai, C H, Wang, H S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734825/
https://ncbi.nlm.nih.gov/pubmed/23449448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.38
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