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Discovery of Histone Modification Crosstalk Networks by Stable Isotope Labeling of Amino Acids in Cell Culture Mass Spectrometry (SILAC MS)

In this paper we describe an approach that combines stable isotope labeling of amino acids in cells culture, high mass accuracy liquid chromatography tandem mass spectrometry and a novel data analysis approach to accurately determine relative peptide post-translational modification levels. This pape...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Guan, Xiaoyan, Rastogi, Neha, Parthun, Mark R., Freitas, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734568/
https://ncbi.nlm.nih.gov/pubmed/23592332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.026716
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