Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

Mutations in the daf-2 gene of the conserved Insulin/Insulin-like Growth Factor (IGF-1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf-16. To uncover regulatory mechanisms coordinating this...

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Detalhes bibliográficos
Main Authors: Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734508/
https://ncbi.nlm.nih.gov/pubmed/23820781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.35
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