Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

BACKGROUND: Insulin signaling is tightly controlled by tyrosine dephosphorylation of the insulin receptor through protein-tyrosine-phosphatases (PTPs). DEP-1 is a PTP dephosphorylating tyrosine residues in a variety of receptor tyrosine kinases. Here, we analyzed whether DEP-1 activity is differenti...

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Detalhes bibliográficos
Main Authors: Krüger, Janine, Trappiel, Manuela, Dagnell, Markus, Stawowy, Philipp, Meyborg, Heike, Böhm, Christian, Bhanot, Sanjay, Östman, Arne, Kintscher, Ulrich, Kappert, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734182/
https://ncbi.nlm.nih.gov/pubmed/23889985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-49
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