Development of p21 Activated Kinase-Targeted Multikinase Inhibitors That Inhibit Thyroid Cancer Cell Migration

CONTEXT: The p21 activated kinases (PAKs) are a family of serine/threonine kinases that are downstream effectors of small GTPase Cdc42 and Rac. PAKs regulate cell motility, proliferation, and cytoskeletal rearrangement. PAK isoform expression and activity have been shown to be enhanced in cancer and...

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Detalhes bibliográficos
Main Authors: Ma, Yihui, McCarty, Samantha K., Kapuriya, Naval P., Brendel, Victoria J., Wang, Chaojie, Zhang, Xiaoli, Jarjoura, David, Saji, Motoyasu, Chen, Ching-Shih, Ringel, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Hot Topics in Translational Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733855/
https://ncbi.nlm.nih.gov/pubmed/23709653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-3937
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