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Clonal Expansion Analysis of Transposon Insertions by High-Throughput Sequencing Identifies Candidate Cancer Genes in a PiggyBac Mutagenesis Screen

Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...

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Detalhes bibliográficos
Main Authors: Friedel, Roland H., Friedel, Caroline C., Bonfert, Thomas, Shi, Ruijin, Rad, Roland, Soriano, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733837/
https://ncbi.nlm.nih.gov/pubmed/23940809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072338
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