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Enantioselective Synthesis of (Z)-2-Methyl-1,5-anti- and (E)-2-Methyl-1,5-anti-Pentenediols Via an Allene Hydroboration-Double Allylboration Reaction Sequence

Kinetic controlled hydroboration of allenylboronate 5 followed by double allylboration with resulting allylborane (Z)-7 gave (Z)-2-methyl-1,5-anti-pentenediols 6 in good yield and high enantioselectivity in the presence of 10% BF(3)•OEt(2) as the catalyst in the second allylboration step. Under ther...

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Bibliographic Details
Main Authors: Chen, Ming, Roush, William R.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733567/
https://ncbi.nlm.nih.gov/pubmed/23758559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4033633
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