A novel concept for ligand attachment to oligonucleotides via a 2′-succinyl linker

Conjugation of ligands to antisense oligonucleotides is a promising approach for enhancing their effects. In this report, a new method for synthesizing oligonucleotide conjugates is described. 2′-Amino-2′-deoxy-5′-dimethoxytrityl-uridine was select ively acylated with a succinic acid linker at the 2...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Winkler, Johannes, Urban, Ernst, Losert, Doris, Wacheck, Volker, Pehamberger, Hubert, Noe, Christian R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2004
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14757835/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh229
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