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A novel concept for ligand attachment to oligonucleotides via a 2′-succinyl linker
Conjugation of ligands to antisense oligonucleotides is a promising approach for enhancing their effects. In this report, a new method for synthesizing oligonucleotide conjugates is described. 2′-Amino-2′-deoxy-5′-dimethoxytrityl-uridine was select ively acylated with a succinic acid linker at the 2...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373351/ https://ncbi.nlm.nih.gov/pubmed/14757835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh229 |
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