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DNA strands with alternating incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes†

Detection of nucleic acids using fluorophore-modified oligonucleotides forms the basis of many important applications in molecular biology, genetics and medical diagnostics. Here we demonstrate that DNA strands with central segments of alternating locked nucleic acid (LNA) and 2'-O-(pyren-1-yl)...

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Main Authors: Karmakar, Saswata, Hrdlicka, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733389/
https://ncbi.nlm.nih.gov/pubmed/23930202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3SC50726B
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