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Transglutaminase-catalyzed Transamidation: A Novel Mechanism for Rac1 Activation by 5-HT(2A) Receptor Stimulation
Transglutaminase (TGase)-induced activation of small G proteins via 5-HT(2A) receptor signaling leads to platelet aggregation (Walther et al., 2003). We hypothesize that stimulation of 5-HT(2A) receptors in neurons activates TGase, resulting in transamidation of serotonin to a small G protein, Rac1,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733250/ https://ncbi.nlm.nih.gov/pubmed/18400843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.135046 |
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