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Linking functional decline of telomeres, mitochondria and stem cells during ageing

The study of human genetic disorders and mutant mouse models has provided evidence that genome maintenance mechanisms, DNA damage signalling and metabolic regulation cooperate to drive the ageing process. In particular, age-associated telomere damage, diminution of telomere ‘capping’ function and as...

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Autores principales: Sahin, Ergün, DePinho, Ronald A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733214/
https://ncbi.nlm.nih.gov/pubmed/20336134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08982
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