Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis

Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium phenylbutyrate (NaPBA), mediates waste nitrogen excretion via combination of PBA-derived phenylacetic acid with glutamine to form phenylactylglutamine (PAGN) that is excreted in urine. Glycerol phenylb...

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Main Authors: MCGuire, Brendan M., Zupanets, Igor A., Lowe, Mark E., Xiao, Xunjun, Syplyviy, Vasyliy A., Monteleone, Jon, Gargosky, Sharron, Dickinson, Klara, Martinez, Antonia, Mokhtarani, Masoud, Scharschmidt, Bruce F.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733097/
https://ncbi.nlm.nih.gov/pubmed/20512995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23589
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