Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic β-cells

Leptin is a pivotal regulator of energy and glucose homeostasis, and defects in leptin signaling result in obesity and diabetes. The ATP-sensitive potassium (K(ATP)) channels couple glucose metabolism to insulin secretion in pancreatic β-cells. In this study, we provide evidence that leptin modulate...

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Autori principali: Park, Sun-Hyun, Ryu, Shin-Young, Yu, Weon-Jin, Han, Young Eun, Ji, Young-Sun, Oh, Keunhee, Sohn, Jong-Woo, Lim, Ajin, Jeon, Jae-Pyo, Lee, Hyunsu, Lee, Kyu-Hee, Lee, Suk-Ho, Berggren, Per-Olof, Jeon, Ju-Hong, Ho, Won-Kyung
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732963/
https://ncbi.nlm.nih.gov/pubmed/23858470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216351110
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