IL-22–producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium sulfate-induced mouse model of acute colitis, we observed an IL-23–dependent up-regulation of IL-22 in the middle and distal colon at the onset of epithelial cell damage. This heightened IL-22 correlated wit...

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Detaylı Bibliyografya
Asıl Yazarlar: Zindl, Carlene L., Lai, Jen-Feng, Lee, Yun Kyung, Maynard, Craig L., Harbour, Stacey N., Ouyang, Wenjun, Chaplin, David D., Weaver, Casey T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732935/
https://ncbi.nlm.nih.gov/pubmed/23781104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300318110
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