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Lysosomal Hydrolase Mannose 6-Phosphate Uncovering Enzyme Resides in the trans-Golgi Network

A crucial step in lysosomal biogenesis is catalyzed by “uncovering” enzyme (UCE), which removes a covering N-acetylglucosamine from the mannose 6-phosphate (Man-6-P) recognition marker on lysosomal hydrolases. This study shows that UCE resides in the trans-Golgi network (TGN) and cycles between the...

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Bibliografiske detaljer
Main Authors: Rohrer, Jack, Kornfeld, Rosalind
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC37329/
https://ncbi.nlm.nih.gov/pubmed/11408573
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