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Lysosomal Hydrolase Mannose 6-Phosphate Uncovering Enzyme Resides in the trans-Golgi Network

A crucial step in lysosomal biogenesis is catalyzed by “uncovering” enzyme (UCE), which removes a covering N-acetylglucosamine from the mannose 6-phosphate (Man-6-P) recognition marker on lysosomal hydrolases. This study shows that UCE resides in the trans-Golgi network (TGN) and cycles between the...

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Pubblicato in:Mol Biol Cell
Autori principali: Rohrer, Jack, Kornfeld, Rosalind
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Cell Biology 2001
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37329/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11408573/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.12.6.1623
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