PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating graft-versus-host-disease

Efforts to limit graft-versus-host disease (GVHD) mediated by alloreactive donor T cells after allogeneic bone marrow transplantation (allo-BMT) are limited by a concomitant decrease in graft-versus-tumor (GVT) activity and increased possibilities of tumor relapse. Using a novel approach, we adoptiv...

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Hlavní autoři: Ghosh, Arnab, Holland, Amanda M., Dogan, Yildirim, Yim, Nury L., Rao, Uttam K., Young, Lauren F., West, Mallory L., Singer, Natalie V., Lee, Hae, Na, Il-Kang, Tsai, Jennifer J., Jenq, Robert R., Penack, Olaf, Hanash, Alan M., Lezcano, Cecilia, Murphy, George, Liu, Chen, Sadelain, Michel, Sauer, Martin G., Sant’Angelo, Derek, van den Brink, Marcel R.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732814/
https://ncbi.nlm.nih.gov/pubmed/23733752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4699
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