LIN28 expression in malignant germ cell tumors down-regulates let-7 and increases oncogene levels

Despite their clinico-pathologic heterogeneity, malignant germ-cell-tumors (GCTs) share molecular abnormalities that are likely to be functionally important. In this study, we investigated the potential significance of down-regulation of the let-7 family of tumor-suppressor microRNAs in malignant-GC...

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Detalhes bibliográficos
Main Authors: Murray, Matthew J., Saini, Harpreet K., Siegler, Charlotte A., Hanning, Jennifer E., Barker, Emily M., van Dongen, Stijn, Ward, Dawn M., Raby, Katie L., Groves, Ian J., Scarpini, Cinzia G., Pett, Mark R., Thornton, Claire M., Enright, Anton J., Nicholson, James C., Coleman, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732484/
https://ncbi.nlm.nih.gov/pubmed/23774216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2085
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