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GPR88 Reveals a Discrete Function of Primary Cilia as Selective Insulators of GPCR Cross-Talk

A number of G protein-coupled receptors (GPCRs) localize to primary cilia but the functional significance of cilia to GPCR signaling remains incompletely understood. We investigated this question by focusing on the D1 dopamine receptor (D1R) and beta-2 adrenergic receptor (B2AR), closely related cat...

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Bibliographic Details
Main Authors: Marley, Aaron, Choy, Regina Wai-Yan, von Zastrow, Mark
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732291/
https://ncbi.nlm.nih.gov/pubmed/23936473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070857
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