Pharmacometabolomic Signature of Ataxia SCA1 Mouse Model and Lithium Effects

We have shown that lithium treatment improves motor coordination in a spinocerebellar ataxia type 1 (SCA1) disease mouse model (Sca1(154Q/+)). To learn more about disease pathogenesis and molecular contributions to the neuroprotective effects of lithium, we investigated metabolomic profiles of cereb...

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Main Authors: Perroud, Bertrand, Jafar-Nejad, Paymaan, Wikoff, William R., Gatchel, Jennifer R., Wang, Lu, Barupal, Dinesh K., Crespo-Barreto, Juan, Fiehn, Oliver, Zoghbi, Huda Y., Kaddurah-Daouk, Rima
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732229/
https://ncbi.nlm.nih.gov/pubmed/23936457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070610
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