Establishment of a Shigella sonnei human challenge model in Thailand()

In order to establish a human challenge model of Shigella related disease for vaccine testing, a dose-escalating inpatient trial was performed. Three groups of 12 healthy adult volunteers were orally challenged with 93,440 and 1680 CFU of Shigella sonnei strain 53G. Subjects were admitted to the Vac...

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Autori principali: Bodhidatta, Ladaporn, Pitisuttithum, Punnee, Chamnanchanant, Supat, Chang, Karen T., Islam, Dilara, Bussaratid, Valai, Venkatesan, Malabi M., Hale, Thomas L., Mason, Carl J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732056/
https://ncbi.nlm.nih.gov/pubmed/23069701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.09.061
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