An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

Small noncoding antisense RNAs (sasRNAs) guide epigenetic silencing complexes to target loci in human cells and modulate gene transcription. When these targeted loci are situated within a promoter, long-term, stable epigenetic silencing of transcription can occur. Recent studies suggest that there e...

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Detalhes bibliográficos
Main Authors: Ackley, Amanda, Lenox, Alexandra, Stapleton, Kenneth, Knowling, Stuart, Lu, Tim, Sabir, Kenny S, Vogt, Peter K, Morris, Kevin V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731886/
https://ncbi.nlm.nih.gov/pubmed/23839098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.33
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