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Monitoring futility in a two-by-two factorial design: The SPS3 experience
BACKGROUND: For studies with two-by-two factorial designs, the complexity of determining an appropriate futility analysis plan is increased as compared to studies where patients are randomized to one treatment. Issues that must be addressed include the possibility of a significant interaction and th...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731445/ https://ncbi.nlm.nih.gov/pubmed/23378483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774512474374 |
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