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Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites. However, recent work has identified a splice variant of Chk1,...

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Main Authors: Patil, Mallikarjun, Pabla, Navjotsingh, Dong, Zheng
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731415/
https://ncbi.nlm.nih.gov/pubmed/23508805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-013-1307-3
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