Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α

Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B and TNF) coding for these two cytokines. Prior t...

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Main Authors: Adamik, Juraj, Wang, Kent Z. Q., Unlu, Sebnem, Su, An-Jey A., Tannahill, Gillian M., Galson, Deborah L., O’Neill, Luke A., Auron, Philip E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731334/
https://ncbi.nlm.nih.gov/pubmed/23936458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070622
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