Phosphorylation of IRF8 in a Pre-associated Complex with Spi-1/PU.1 and Non-phosphorylated Stat1 is Critical for LPS Induction of the IL1B Gene

Rapid induction of transcription is known to be mediated by factors which bind DNA following post-translational modification. We report here that non-tyrosine phosphorylated (NTP)-Stat1 is involved in a cooperative interaction with Spi-1/PU.1 and IRF8 to form a pre-associated, poised complex is for...

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Detalhes bibliográficos
Main Authors: Unlu, Sebnem, Kumar, Arvind, Waterman, Wayne R., Tsukada, Junichi, Wang, Kent Z.Q., Galson, Deborah L., Auron, Philip E
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719065/
https://ncbi.nlm.nih.gov/pubmed/17386941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2007.02.016
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