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A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC(50)
The half-maximal inhibitory concentration IC[Image: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic sigmoidal models. However, recent studies on Hum...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731310/ https://ncbi.nlm.nih.gov/pubmed/23936323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069301 |
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