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A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC(50)

The half-maximal inhibitory concentration IC[Image: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic sigmoidal models. However, recent studies on Hum...

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書誌詳細
主要な著者: Zhang, Hui, Holden-Wiltse, Jeanne, Wang, Jiong, Liang, Hua
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731310/
https://ncbi.nlm.nih.gov/pubmed/23936323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069301
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