Isoniazid Inhibits the Heme-Based Reactivity of Mycobacterium tuberculosis Truncated Hemoglobin N

Isoniazid represents a first-line anti-tuberculosis medication in prevention and treatment. This prodrug is activated by a mycobacterial catalase-peroxidase enzyme called KatG in Mycobacterium tuberculosis), thereby inhibiting the synthesis of mycolic acid, required for the mycobacterial cell wall....

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Bibliographic Details
Main Authors: Ascenzi, Paolo, Coletta, Andrea, Cao, Yu, Trezza, Viviana, Leboffe, Loris, Fanali, Gabriella, Fasano, Mauro, Pesce, Alessandra, Ciaccio, Chiara, Marini, Stefano, Coletta, Massimo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731299/
https://ncbi.nlm.nih.gov/pubmed/23936350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069762
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