TNF-α and CD8(+) T Cells Mediate the Beneficial Effects of Nitric Oxide Synthase-2 Deficiency in Pulmonary Paracoccidioidomycosis

BACKGROUND: Nitric oxide (NO), a key antimicrobial molecule, was previously shown to exert a dual role in paracoccidioidomycosis, an endemic fungal infection in Latin America. In the intravenous and peritoneal models of infection, NO production was associated with efficient fungal clearance but also...

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Main Authors: Bernardino, Simone, Pina, Adriana, Felonato, Maíra, Costa, Tânia A., Frank de Araújo, Eliseu, Feriotti, Cláudia, Bazan, Silvia Boschi, Keller, Alexandre C., Leite, Katia R. M., Calich, Vera L. G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731220/
https://ncbi.nlm.nih.gov/pubmed/23936574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002325
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