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Full Design Automation of Multi-State RNA Devices to Program Gene Expression Using Energy-Based Optimization
Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 5′ untranslated region of the mRNA. We have developed a physicochemical framework, relying on base pair interaction energies, to design multi-state sRNA devices by solving an optimization proble...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science
2013
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731219/ https://ncbi.nlm.nih.gov/pubmed/23935479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003172 |
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