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Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc()

We report the characterization of tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable zinc chelator for intercepting biological mobile zinc. Compared to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), TPA chelates zinc with faster kinetics in cuvettes, live cells, and brain...

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Bibliografiset tiedot
Päätekijät: Huang, Zhen, Zhang, Xiao-an, Bosch, Miquel, Smith, Sarah, Lippard, Stephen J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730853/
https://ncbi.nlm.nih.gov/pubmed/23715510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mt00103b
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